Is there a role for cyclophosphamide in refractory digital ischemia in patients with scleroderma?

Great question!

The vascular disease in Scleroderma (Systemic sclerosis/SSc) is characterized by vasospasm, a proliferative vasculopathy with intimal hyperplasia, thrombosis and/or occlusive (fibro-obliterative) arterial disease with near blockage of the vascular lumen in many cases and impaired ang...