Is there a situation where you would use a purine analogue in combination with rituximab for the frontline line treatment of normal variant Hairy Cell Leukemia?

This is an excellent question, and I was assisted in this answer by Drs. @Dr. First Last and @Dr. First Last who are both hairy cell leukemia experts since there is really not a lot of trial data to guide this answer. There is limited data for the addition of rituximab in the frontline setting in vH...