Is there an SIB boost regimen for a dominant prostate lesion for 60 Gy/20 fx to the whole prostate?

There are no phase III data providing guidance on the "isotoxic" boost dose for a 20-fraction, hypofractionated prostate treatment similar to the experimental arm in FLAME (Kerkmeijer et al., PMID 33471548), but there are two prospective studies of which I am aware, DELINEATE and ARO2020-01, which d...

Dr. @Dr. First Last has a good summary of the data. Outside of that, the NRG GU-010 trial allows for microboost and offers guidance for different dose/fractionation regimens based on BED conversions assuming an alpha/beta of 3. If using these non-validated regimens, I would encourage anyone to appro...

40 Gy/20 fractions is highly likely to eradicate subclinical carcinoma so 60/40 would be a good choice.