What are the clear criteria for unresectability in locally advanced NSCLC patients, other than medical or anatomic?   

Medical inoperability is clearly defined, anatomical resectability is also pretty much clear (invasion of trachea/carina/esophagus, etc). But what about "oncological-meaningful" resectability? Bulky N2? Multi-Level N2? Many of these tumors are "technically" resectable, yet have a bad prognosis, so that we often opt for concurrent chemo-RT + durvalumab. Does a clearly defined list of such criteria exist?

Answer from: at Academic Institution