What are the treatment implications for use of PARP inhibitors in patients with metastatic triple negative breast cancer with a germline vs somatic BRCA muation?
Answer from: Medical Oncologist at Academic Institution
To date, we only have results supporting the use of PARP inhibitors in breast cancer patients with germline BRCA1/2 mutations and advanced HER2 negative breast cancer. Studies are being initiated to explore the use in breast cancers harboring somatic mutations (NCT03990896). Enrollment in thes...