What are your current recommendations for treatment of symptomatic splenomegaly in the setting of myelofibrosis when splenectomy is not an option?

Is there a preferred low dose splenic irradiation regimine?

Answer from: Radiation Oncologist at Academic Institution

I use low dose, typically 50cGy per fraction for 4-6 fractions, done in 2 fractions per week; need to check platelets each week during course.