What characteristics make a PMR patient a good candidate for sarilumab?
Do you plan to use sarilumab for all patients with relapsing or refractory PMR or are there certain features that will make you more or less likely to recommend it?
This question is part of a collaboration with RheumMadness and is specifically in reference to: SAPHYR
Answer from: at Academic Institution
As rheumatologists, we are familiar with sarilumab, so we may already be comfortable using this medication. It has a role to play in managing patients with some of the following issues:
Those who are struggling with early steroid tapers, i.e., not successfully tapering from 10 down to 5 mg/qd.
P...
Sign in or Register to read more
Answer from: at Community Practice
Patients at high risk for glucocorticoid toxicity based on co-morbidities are especially appealing candidates for sarilumab. Likewise, I think patients with a history of multiple relapses as well as those with the inability to taper less than 7.5mg of prednisone daily without recurrent signs/symptom...
Answer from: at Academic Institution
In patients with Polymyalgia Rheumatica if it is hard to taper their steroid use, I would add Sarilumab as a fracture in the vertebra is pain for life.
Answer from: at Academic Institution
There exists a major confounding factor that negates any prior researcher’s claim of properly stratifying PMR patients into clear-cut diagnostic categories before treatment. It has been reported that an average of 8 & 1/2 to 9 months elapse from the time of PMR onset for those patients who...