What dose and target volume do you use for neoadjuvant chemoRT in a patient with a locally advanced uterine/endometrial cancer involving parametria, cervix, and the uterine fundus (no side wall involvement) requiring downstage to be eligible for surgery?

Presuming that this is an endometrioid cancer - I would start with RT +/- chemo. There is potential for there to be sufficient shrinkage to facilitate brachytherapy boost. I do appreciate the link Dr. @Dr. First Last published, and would consider doing SBRT with a neoadjuvant dose how we would as pe...

This is our series and approach; Vargo et al., PMID 25218303.

A few points in this series did have interstitial brachytherapy with the goal of focusing more on areas where downsizing will make surgery feasible.