What guides your choice between prophylactic, intermediate, and full therapeutic dosing of enoxaparin in a woman with APLS and prior fetal loss with no hx of thromboembolic disease?

First, it is essential to confirm that patients meet criteria for obstetric antiphospholipid antibody syndrome (OAPS), based on the 2023 ACR/EULAR classification criteria. This includes persistently positive laboratory criteria (confirmed on repeat testing >12 weeks apart), plus otherwise unexplaine...

This topic is addressed in the 2020 ACR Reproductive Health guidelines.

This patient has obstetric APS, assuming they meet the lab criteria for such. Therefore, they should be on low-dose aspirin and prophylaxis with LMWH.

I do think it's important to consider that if she doesn't meet the official cri...