What is the evidence/rationale for not treating neuroblastoma metastatic sites which are MIBG negative after induction chemo?

A clinically meaningful number of high-risk neuroblastoma patients are curable, which in part justifies metastasis-directed local therapy. It can be difficult though to balance the toxicity of multi-site irradiation with maximum control of sites of metastatic disease. Metastases that persist after i...