What is the preferred four-drug regimen for initial treatment of pan-susceptible tuberculous meningitis, given the need to achieve optimal CNS penetration?  

I will defer to the guidelines for the specific regimen. One general issue I would like to address is the idea of "CNS penetration." Since we don't routinely do brain biopsies in humans to truly assess levels of antimicrobials in the brain/spinal cord/meninges, many people think that "CSF levels = C...

The recommended regimen is the same as for pulmonary TB, and most people are treated longer than for pulmonary TB. However, there are several things to consider given the concern for CNS penetration of drugs. Some experts increase the Rifampin dose to make it 20 mg/kg, not the usual 10 mg per kilog...