What is the role for TTFields in patients who cannot undergo complete surgical resection for glioblastoma?

A gross total resection is not a requirement for the use of TTF, and therefore these patients can be evaluated for this therapeutic option.

The EF14 trial included newly diagnosed glioblastoma patients who had gross total resections and those who had biopsies. Only 54% of patients had a GTR and 13% had biopsy. TTF plus temzolomide was associated with an increase in PFS and OS in all subgroups including extent of resection. So even if gr...