What is your adjuvant therapy for node positive, low grade endometrioid endometrial adenocarcinoma?

Chemotherapy (typically carboplatin/paclitaxel x 6 cycles), restage, and if no progression, whole-pelvic RT. Consider brachytherapy boost if cervical stromal or vaginal involvement and/or presence of other risk factors for vaginal cuff recurrence (e.g. LVSI, deep myometrial invasion, grade 3 [not in...

In addition to Dr. @Dr. First Last's option of sequential chemotherapy followed by radiation +/- brachytherapy, there are a few other options that are also very reasonable:

1) Concurrent chemoradiation with 2 cycles Cisplatin followed by consolidation chemotherapy - the experimental arms of both GOG ...

Currently, most treat with sequential chemotherapy plus EBRT. Although if it is POLE type, then the value of chemotherapy is debatable (PORTEC-3) and that’s why current ESTRO guidelines didn’t come out with specific recommendations for stage III POLE type.