Hypergammaglobulinemia and hypocomplementemia are risk factors for lymphoma in the setting of Sjogren's Disease (SjD), as well as cryo, IgM kappa, lymphopenia/neutropenia, RF+, asymmetric parotid swelling and disease activity (Nocturne et al., PMID 26606524). Therefore, even with "minimal symptoms" ...

I treat these patients. In the past, many Sjogren's patients didn't seek medical care or weren't referred by other providers until quite end-stage sicca symptoms. Now we are getting better at recognizing Sjogren's many early symptoms, not just sicca, and instead of the stereotypical middle-aged woma...

I agree with Dr. @Carteron. I offer hydroxychloroquine to nearly all Sjogrens patients with systemic features whether clinical and/or biochemical. I tell them the evidence behind this may not be strong but for some subset of patients, it can be quite helpful. Many patients worry about potential reti...