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What is your approach to neoadjuvant treatment for uterine carcinosarcoma with peritoneal metastases prior to surgical debulking?

When might you consider somatic next generation sequencing for this disease?
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What is your approach to neoadjuvant treatment for uterine carcinosarcoma with peritoneal metastases prior to surgical debulking?

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1 Answer
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Medical Oncology · University of Utah School of Medicine
Answered on

Uterine carcinosarcoma is treated as a high-grade epithelial endometrial carcinoma, and for a patient with peritoneal metastases who is not a candidate for upfront optimal cytoreduction, the standard neoadjuvant approach is systemic chemotherapy with carboplatin/paclitaxel followed by re-evaluation ...

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