What is your criteria for undetectable PSA value after prostatectomy?
NRG GU-006 included the following as part of its eligibility criteria: “Persistent elevation of PSA after prostatectomy measured within 90 days after surgery (PSA never became undetectable) of >0.04 but <0.2 ng/mL (PSA nadir).” Is this your current approach? Does the presence of any PSA, even at lower values, impact your treatment recommendations?
2 Answers
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Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
In the era of ultra-sensitive PSA, reading below threshold of .2 ng/ml also reflects biochemical recurrence especially in the right context.
That being said, if values are low like above, we generally repeat PSA to see the trend rather than act on treatment on single value.
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Radiation Oncology
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It probably depends on the exact reason for the classification, but presumably, it is to decide when to offer early salvage RT. For this, I have been relying on the definitions from RADICALS-RT, GETUG-AFU 17, and RAVES. RADICALS-RT included men with a post-op PSA ≤ 0.2. GETUG-AFU 17 included men wit...
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