What is your preferred adjuvant chemotherapy regimen for a patient with local recurrence of TNBC two years after completing neoadjuvant ddAC-T who declined prior adjuvant capecitabine?

Topics: Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Triple negative • University of Iowa • NCI-CCC Breast Tumor Board Question

Had mastectomy resulting in ypT1cN1a. Post menopausal female with good PS.

Answer from: Medical Oncologist at Academic Institution

There is no clear data-driven option for a patient with TNBC local recurrence, although the underpowered CALOR study does support the use of chemotherapy in the local recurrence setting. I would offer this patient a taxane + carbo + pembro for 4-6 cycles if she doesn't have significant neuropathy. T...

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Medical Oncologist at Sarah Cannon Cancer Institute at Menorah Medical Center
I agree with @Amye Tevaarwerk. I prefer to offer t...

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