What is your preferred agent for fungal prophylaxis in a patient post lung transplant with abnormal LFTs?
5
2 Answers
Mednet Member
Pulmonology · Hospital of the University of Pennsylvania
Isavuconazonium tends to cause less elevations in LFTs.
Mednet Member
Pulmonology · University of Colorado School of Medicine
Answer: Isavuconazole
Rationale:
Azole hepatotoxicity in my experience is ranked as following:
Voriconazole>Posaconazole>isavuconazole or itraconazole or fluconazole.
Therefore, my choice for lung transplant fungal prohylaxis is either itraconazole or isavuconazole if there is not pre-transplant col...