What is your preferred agent for fungal prophylaxis in a patient post lung transplant with abnormal LFTs?
Do you consider isavuconazole to be less hepatotoxic than other azoles?
2 Answers
Mednet MemberInvited Expert
Pulmonology · Hospital of the University of Pennsylvania
Answered on
Isavuconazonium tends to cause less elevations in LFTs.
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Mednet MemberInvited Expert
Pulmonology · University of Colorado School of Medicine
Answered on
Answer: Isavuconazole
Rationale:
Azole hepatotoxicity in my experience is ranked as following:
Voriconazole>Posaconazole>isavuconazole or itraconazole or fluconazole.
Therefore, my choice for lung transplant fungal prohylaxis is either itraconazole or isavuconazole if there is not pre-transplant col...
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