What is your preferred conditioning regimen for fit patients with high-risk MDS undergoing MUD allogeneic stem cell transplantation?
How do you choose between RIC compared to MAC? Is there evidence for one over the other in an otherwise healthy, young patient?
Do you include hypomethylating agents as part of your regimen?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Maryland Cancer Center
Answered on
The short answer is whatever MAC regimen you and your center are familiar with and comfortable managing the side effects. I would definitely think of a myeloablative regimen rather than a reduced intensity one. For HLA-matched donor, I usually give MAC Bu4Flu with Bu PK to tailor the Bu dose.
The BMT CTN 0901 put the question of MAC vs RIC at rest and is in favor of MAC for eligible patients although the difference was more striking in AML than MDS - Scott et al., PMID 28380315.
Hypomethylating a...
Join for free or sign in to see the full answer