What is your preferred conditioning regimen for fit patients with high-risk MDS undergoing MUD allogeneic stem cell transplantation?
How do you choose between RIC compared to MAC? Is there evidence for one over the other in an otherwise healthy, young patient?
Do you include hypomethylating agents as part of your regimen?
Answer from: Medical Oncologist at Academic Institution
The short answer is whatever MAC regimen you and your center are familiar with and comfortable managing the side effects. I would definitely think of a myeloablative regimen rather than a reduced intensity one. For HLA-matched donor, I usually give MAC Bu4Flu with Bu PK to tailor the Bu dose. T...
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