What is your typical duration and route of treatment for a lytic lesion in the metaphysis of a long bone secondary to MSSA, i.e., a Brodie abscess, following debridement in an immunocompetent patient?

For native bone osteomyelitis (including Brodie abscess) with residual infected bone after debridement, antibiotic therapy is usually recommended for 6 weeks from the date of last debridement. Data suggest that a duration of antibiotic therapy beyond 6 weeks is usually unnecessary if necrotic bone and soft tissue have been adequately removed during surgery. Both intravenous and oral antibiotic regimens are supported by randomized trials, provided oral antibiotics have good oral bioavailability and the patient meets criteria for treatment with oral therapy.