What radiation sensitizer do you recommend for early stage poorly differentiated squamous cell carcinoma of the anus, in a patient with stage IV chronic kidney disease?
For a patient not on dialysis? Outside of single agent 5FU, all other standard chemotherapeutic options would be contraindicated for nephrotoxicity.
Answer from: Medical Oncologist at Academic Institution
I have used carboplatin (AUC 2 weekly) + 5-fluorouracil in this setting with good tolerance. I acknowledge that the substitution of carboplatin for cisplatin is largely an extrapolation from the approach to squamous cell carcinomas of other primary sites. However, I feel very comfortable with this s...
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