What strategies can we use to help patients receiving Dato-DXd report symptoms earlier, with the goal of early intervention to prevent progression to higher grade side effects?  

Educating and encouraging patients to report toxicities as early as possible is key to recognizing and preventing higher-grade toxicity. When feasible, having oncology nurse navigators/ancillary staff check in with patients during the first few cycles of treatment (C1D14 to C3D1) can be helpful, giv...

Patients should get a thorough history and physical with each treatment by a medical provider, including a review of their history on signs and symptoms of oral pain, swallow difficulty, dry mouth, and food intolerance. In addition, patients should get an oral cavity examination to examine for signs...

Patient education is needed to prevent progression to higher-grade mucositis/stomatitis. Patients should be informed when to reach out to care teams if they are developing symptoms despite prophylactic mouthwash. Aside from mouthwash, cryotherapy (ice chips) can be used during infusions. Topical lid...