What would you your approach to evaluation and monitoring of a patient with elevated AMA and increased immunoglobulins with a low alkaline phosphatase?
1 Answers
Mednet Member
Hepatology · University of Chicago
The diagnosis of PBC requires 2 of the 3 following elements:
- Positive AMA,
- Elevated ALP, and
- Biopsy consistent with PBC.
It is quite possible this person will develop an elevated ALP in time. I would follow liver enzymes yearly, but would not diagnose PBC until the ALP increases. I would start UDC...