When do you stop dantrolene in a patient with neuroleptic malignant syndrome?
Is it reasonable to stop dantrolene if CPKs are stable and autonomic symptoms have improved or do you continue treatment for a certain amount of time post recovery?
Answer from: at Academic Institution
Dantrolene is typically used to treat severe NMS, although the data supporting its use is mixed. The biggest risk with the therapy is hepatotoxicity. It is reasonable to discontinue dantrolene once the hyperthermia and severe muscle rigidity have resolved, or earlier if there is concern for liver in...