When treating locally advanced breast cancer preoperatively that is progressing on neoadjuvant chemotherapy, to what doses do you treat the gross disease, breast, and regional nodes?

I typically treat 50 Gy to large fields including the entire breast and regional nodes and take any gross disease to 60-66 Gy. I also discuss with my medical oncologist the possibility of concurrent xeloda as well.

Treat with radiation doses between 50 to 60 Gy, with higher end of dose to the nodal location which could not be removed with surgery.