When would you consider fulvestrant + alpelisib in a postmenopausal patient who has HR+, PIK3CA mutant, metastatic breast cancer instead of initial CDK4/6 inhibitor therapy?
Answer from: Medical Oncologist at Academic Institution
Given that SOLAR-1 study enrolled patients who previously progressed after at least 1 line of endocrine therapy for metastatic disease, I would not offer alpelisib as front line therapy. My preference for front line therapy for metastatic, HR+, PIK3CA mutation-positive breast cancer is a combination...
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Medical Oncologist at UPMC Cancer Center I agree with @Robert Wesolowski and am very comfor...
I agree with @Robert Wesolowski and am very comfor...