Which ANCA vasculitis patients are better candidates for cyclophosphamide rather than rituximab?

Both can be used for induction in GPA/MPA vasculitis. I would use rituximab (RTX) if the patient has previously been treated with cyclophosphamide (CYC) and developed a relapse/flare and in patients who are young and with fertility concerns. In GPA/MPA, I tend to use RTX most of the time for inducti...

Another controversial issue! I have not seen convincing evidence that the effect of cyclophosphamide in ANCA-associated vasculitis is “faster” than the effect of rituximab; there are data from RAVE of equal time to remission for these two treatments. Remember that treatment trials of AAV (until ADVO...