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Which regimen is better for gastric adenocarcinoma- neoadjuvant chemotherapy or adjuvant chemoradiation?

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Mednet Member
Mednet Member
Radiation Oncology · Rutgers Robert Wood Johnson Medical School

There are common criticisms of both the MAGIC and INT-0116 trial results.

In the MAGIC trial consisting of preoperative (3 cycles ECF) and postoperative (3 cycles of ECF) vs surgery alone, there was inconsistent preoperative staging.. Lymph node dissections were left to the discretion of the surgeon ...

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Mednet Member
Mednet Member
Radiation Oncology · Brigham and Women's Hospital

The differences in the design of these trials make it impossible to compare the results. Both are viable options. People, and institutions, certainly have preferences for one approach vs. the other, but I would not say there is a consensus.

My personal preference is for pre-operative chemoradiation, ...

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Which regimen is better for gastric adenocarcinoma- neoadjuvant chemotherapy or adjuvant chemoradiation? | Mednet