With a head and neck squamous cell of of unknown primary, do you typically treat the larynx?

Not routinely unless the clinical picture really strongly points to the larynx/hypopharynx e.g. p16- and the only nodes or the largest nodes are in level 3-4. It goes without saying that there should be an extensive search process with experienced surgical and radiologic input to try to find the pri...

No; While the advocated MDA approach was to treat the entire pharyngeal axis (which would include the larynx), we have moved away from routine treatment of the larynx/hypopharynx except in the situation of an HPV/p16 -ve node in a heavy smoker.