With the RAPIDO trial demonstrating efficacy of short course XRT as part of TNT for locally advanced rectal cancer, is there a role for short course XRT to be integrated into watch and wait programs?

Great question, and one our group has discussed extensively.

Our group currently uses short course radiation nearly exclusively in the treatment of locally advanced rectal cancer. One notable exception (at least so far) is if the patient desires NOM. Our rationale is that there aren’t as many data f...

Great question and thank you for the shout-out, Dr. @Dr. First Last!

We completed the NORMAL-R (Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum - NCT02641691) trial. This small study of 19 patients evaluated the clinical complete response (cCR) rate at 1-year (primary endpoin...