Would a finding of isolated tumor cells on SNB impact your decision to offer omission of radiation in a patient with breast cancer who is otherwise a candidate?

ITCs raise our eyebrows, for sure, but are not technically a reason to treat. As this was not recorded in the CALGB study and the majority of patients did not have any axillary evaluation, it is quite likely a portion of patients had ITCs, and yet still did not have excessive rates of recurrence.

Tha...

ITCs would not change the decision in otherwise suitable for AI alone with no RT. That being said, for these patients meeting prime 2 or CALGB, we now favor fast forward whole breast regimen or 5 fraction APBI schedule.