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Would mild hemophilia A that does not require frequent factor replacement be an absolute contraindication to anti-VEGF medications when indicated?

How would you treat metastatic, unresectable, solitary fibrous tumor in a patient with mild hemophilia A? Each anti-VEGF medication comes with a warning of hemorrhage.
1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Cedars-Sinai Medical Center
Answered on

There is one report in the literature of the use of bevacizumab and chemotherapy in a patient with mild Hemophilia B and metastatic colon cancer. The patient tolerated the combination without bleeding and his hematologic monitoring remained unchanged on the combination. The package insert does descr...

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