Would you consider adjuvant TDM-1 for a patient with HR+,HER2+ breast cancer with pCR in the breast but N1mic disease post neoaduvant chemotherapy?
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What adjuvant HER2+ directed therapy would you use for a patient with HR+ HER2+ breast cancer with pCR in the breast but N1mic disease post neoaduvant chemotherapy?
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1 Answer
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Medical Oncology · Icahn School of Medicine at Mount Sinai
Answered on
The Katherine Trial (NEJM 2019:380;617-280) was a randomized trial of trastuzumab emtansine (TDM-1) versus trastuzumab for patients with residual disease after HER2-directed neoadjuvant treatment. The trial was positive for TDM-1. The randomized patients included those with residual invasive disease...
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