Would you consider eliminating PMRT to the chest wall in select cases of T3N0 breast cancer?

There are a number of studies, including the one below, that suggest that favorable ER/PR+, HER2 negative patients with T3N0 have low local recurrence rates without PMRT. Every case is individualized and should take into consideration all factors including size, margins, and other adverse features b...

Also agree with @Dr. First Last. The largest series of T3N0 treated by mastectomy and no PMRT came from NSABP (Taghian et al., PMID 16921044.) showing that without radiation, LRF was <7%. This was a compilation of 5 large randomized studies investigating various chemotherapy regimens. This was also ...

We offer for a very select subset with LVI, triple negative, high Oncotype, or close margin.

I agree with Dr. @Dr. First Last and would also add that such patients may be candidates for the MA39, TAILOR RT trial if Oncotype score is <26.