Would you consider pembrolizumab plus lenvatinib for stage IV uterine carcinosarcoma after progression on chemotherapy as per Keynote-146 and now with Keynote-775?

Yes! Carcinosarcoma is considered a high-grade carcinoma (an epithelial neoplasm, and not a uterine sarcoma). The current FDA approved indication for lenvatinib and pembrolizumab is for those with advanced or recurrent disease that is not MSI-H or dMMR in patients who are not candidates for curative...