Would you give adjuvant endocrine therapy to a premenopausal woman with early stage node positive breast cancer that was ER negative, PR positive (60%) and HER2 positive?

The first thing I would do in this case is have the block retested for ER staining preferably at a different lab. There have been multiple studies published in the past that have shown ER negative PR positive tumors (particularly strong PR staining like this one) frequently end up being ER+ on retes...

Would give only anti HER2 therapy.