Would you offer contralateral prophylactic mastectomy in an older BRCA1 + woman who is getting treated for newly diagnosed BC with mastectomy and SLNB?
Knowing that benefit of contralateral mastectomy is lower in older women who has already manifested BRCA related cancer and 10-20 % mastectomy related complications.
Answer from: Medical Oncologist at Academic Institution
Women with deleterious mutations in BRCA1 typically develop triple negative breast cancers. There is a not-insignificant risk of breast cancer in the contralateral breast after a diagnosis of breast cancer. This risk is as high as 20% within 5 years of the primary diagnosis. Even if detected early, ...
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