Would you offer post-operative radiation therapy for a pseudoendocrine sarcoma with a CTNNB mutation of the spine that has been resected with a positive margin?

I am not aware of any histology-specific data that would alter the otherwise standard approach to such a situation. If I were seeing such a patient, I would:

1. Get MRI to confirm no gross residual disease.
2. Ask the surgeon to re-resect for R0 margins, if at all possible.
3. Treat to 60 Gy postop if so, ...

Pseudoendocrine sarcoma is a rare, distinctive tumor of uncertain lineage with a predilection for paravertebral soft tissue in older adults; it is composed of sheets, trabeculae, and nests of epithelioid or ovoid cells with indistinct borders, palely eosinophilic cytoplasm, and highly monomorphic, r...