Please select the option that best describes you:
Topics:
General Internal Medicine • Primary Care • Geriatric Medicine • Dementia • General Geriatric Medicine • General Primary Care
Would you recommend a GLP-1 agonist as an option to reduce the risk of dementia in patients with a strong family history?
As studied in Tang HDonahoo WTDeKosky ST, et al. GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias. JAMA Neurol. 2025;82(5):439–449. doi:10.1001/jamaneurol.2025.0353
AND
Seminer A, Mulihano A, O'Brien C, Krewer F, Costello M, Judge C, O'Donnell M, Reddin C. Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis. JAMA Neurol. 2025 May 1;82(5):450-460. doi: 10.1001/jamaneurol.2025.0360. PMID: 40193122; PMCID: PMC11976645.
Answer from: at Community Practice
I'm recommending GLP-1 for many things right now, but I haven't yet independently recommended it just to reduce the risk of dementia. However, if microvascular disease can contribute to vascular dementia, then there may be a benefit to better controlling diabetes with this drug.
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