Would you recommend adjuvant capecitabine and radiation in addition to adjuvant FOLFOX for a patient with resected pT3N2 rectosigmoid adenocarcinoma with other high-risk pathologic features?

As with all rectal tumors, those that are labeled as "rectosigmoid" should be reviewed in a multidisciplinary tumor board at a center with deep sub-specialty expertise. In general, radiation is provided for rectal cancers--unlike for colon cancers--because of the increased risk of local recurrence a...

No, there is no evidence of any local control limitation or survival benefit in colon cancer unless there's a perforation. There is no indication for radiation in this case.