Mednet Logo

Would you recommend adjuvant radiation for well-differentiated gastric-type adenocarcinoma of the cervix, stage 1b without LVI?

The limited data on MDA (minimum deviation adenocarcinoma) suggests it has a worse prognosis, but it is hard to disentangle this from stage, as it is more likely to present at late stage. Data suggests relative chemoresistance but it's unclear to me whether there is also relative radioresistance, which would be suggested by the well-differentiated phenotype. For a patient with stage 1b disease, s/p rad hyst, negative margins but deep stromal invasion, "well-differentiated" grade, negative nodes and no LVI, would most recommend adjuvant radiation?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Gynecologic Oncology · Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Answered on

Our tumor board evaluates each case for both Sedlis (GOG 92, PMID:10329031) and Peters (GOG 109, PMID:10764420) regardless of the histologic subtype to determine adjuvant therapy. Here with the deep invasion if the tumor size is >=4cm we would offer adjuvant radiation. You are correct in that there ...

Join for free or sign in to see the full answer