Would you recommend adjuvant radiation for well-differentiated gastric-type adenocarcinoma of the cervix, stage 1b without LVI?   

The limited data on MDA (minimum deviation adenocarcinoma) suggests it has a worse prognosis, but it is hard to disentangle this from stage, as it is more likely to present at late stage. Data suggests relative chemoresistance but it's unclear to me whether there is also relative radioresistance, which would be suggested by the well-differentiated phenotype. For a patient with stage 1b disease, s/p rad hyst, negative margins but deep stromal invasion, "well-differentiated" grade, negative nodes and no LVI, would most recommend adjuvant radiation? 



Answer from: at Community Practice