Cervical Cancer

Assuming patient is <45 years old with cervical, vulvar, vaginal, anal, or head/neck cancers, or with CIN/VIN/VaIN/AIN/ oropharyngeal precancerous ...

2 Answers available

How do you integrate ophthalmic exam and surveillance into routine visits for cervical cancer patients receiving tisotumab vedotin?

2 Answers available

What is your approach to a patient with locally advanced cervical cancer who presents with a fistula (rectal or bladder)?

Do you recommend upfront diversion? Are there unique planning considerations such as the inability to use bladder filling? How do you boost? What are ...

1 Answer available

What is your approach to first line systemic therapy in metastatic PD-L1 positive cervical cancer?

Do you include pembrolizumab with platinum-taxane + bevacizumab or reserve it as a second line option?

1 Answer available

Would you offer brachytherapy for a patient with metastatic cervical cancer s/p 30Gy/10 fx to the pelvis followed by chemotherapy who only has isolated disease in the cervix?

If a patient presents with metastatic disease (by virtue of extensive PA nodal burden, mediastinal/SCV involvement, no solid organs) but received urge...

1 Answer available

For newly diagnosed advanced cervical cancer, how soon after periaortic lymph node evaluation do you start definitive chemoradiation treatment?

Assuming the nodal assessment is minimally invasive and the patient is otherwise healthy without postoperative complications.

1 Answer available

How would you treat cervical stump SCC involving bladder, pelvic nodes, and port-site metastasis in a patient post-laparoscopic hysterectomy?

2 Answers available

What is your preferred management for a patient who was treated with definitive chemoradiation for locally advanced cervical cancer who now has a biopsy-proven isolated brain metastasis 5 years later?

Consideration for localized therapy alone vs. localized therapy + systemic chemotherapy.

1 Answer available

How do you manage a screening pap smear result of HSIL and HPV16+ in a first trimester pregnancy?

1 Answer available

What adjuvant therapy do you recommend for early stage poorly differentiated small cell neuroendocrine carcinoma of the cervix after surgical resection?

2 Answers available

What impacts your decision to use PET vs CT for radiographic staging of clinically locally advanced cervical cancer?

3 Answers available

For a patient with cervical cancer s/p chemoRT, would you consider brachytherapy to downstage tumor to allow for hysterectomy rather than pelvic exenteration?

1 Answer available

What is your fertility-sparing management of a stage IA1 cervical squamous cell carcinoma following a LEEP with negative margins and focal LVSI?

2 Answers available

When do you transfuse cervical cancer patients undergoing chemoradiation?

Do you try to keep Hb> 10 or 12? Or somewhere in between?

2 Answers available

When do you consider re-irradiating patients with recurrent cervical cancer?

2 Answers available

What treatment would you offer a patient with metastatic cervical cancer to the supraclavicular nodes with a complete clinical response in her nodes, but a 3 cm residual in the cervix?

1 Answer available

What dose fractionation would you use on a large retroperitoneal recurrence of cervical cancer that is extending to previously treated 5040cGy pelvis?

1 Answer available

What is your strategy for treatment of FIGO IIB cervical cancer in a patient who poorly tolerated the first insertion and refuses subsequent insertions?

Patient is 38yo, has a history of narcotic abuse, and may have an undiagnosed personality disorder.

2 Answers available

How would you approach treatment for a locally advanced cervical cancer in the context of a completely prolapsed uterus in a non-surgical candidate?

1 Answer available

What is your approach to a cervical cancer in a patient with a previous supra-cervical hysterectomy?

1 Answer available

What palliative regimen do you use for intra-pelvic recurrence of cervical cancer after definitive chemoRT with T&O brachytherapy?

Is the QuadShot a possible option?

1 Answer available

What is your institutional protocol for an incidental finding of an adnexal cyst on CT simulation for cervical cancer?

Could EBRT lead to rupture of the cyst?

2 Answers available

Would one expect any significant response of pulmonary metastases with usual dosage of weekly cisplatin during definitive chemoRT for cervical cancer?

This patient has pulmonary nodules that are too small to characterize.

1 Answer available

How would you manage a patient with 1B2 adenocarcinoma of the endocervix s/p TAH/BSO who was found to have bilateral metastasis to Fallopian tube, a 1 cm pelvic side wall metastasis, and no LN metastasis?

1 Answer available

In what scenario would you give consolidation chemotherapy after chemoradiation for stage 3 cervical cancer with a good response?

3 Answers available

Would you offer any adjuvant therapy for cervical cancer following total pelvic exenteration in the setting of a positive pelvic lymph node?

Previously received pelvic EBRT and intracavitary brachytherapy. IORT was administered to the node-positive side wall at the time of exenteration.

3 Answers available

How would you proceed after complete response to carboplatin/paclitaxel/bevacizumab in a patient who presented with distantly recurrent SCC of the cervix?

Initially treated with definitive chemoRT but recurred with distant mets. Completed 6 cycles carb/tax/bev with minimal toxicity. Excellent performance...

1 Answer available

How would you manage a patient with history of locally advanced SCC of the cervix, treated with definitive chemoRT, found to have new lung lesions 6 months post treatment?

Lung is biopsy proven met cervix, SBRT is planned.

2 Answers available

What would be your treatment approach for a patient with a new PET positive para-aortic node 3 months following completion of definitive chemoradiation for locally advanced cervical cancer?

Patient did not previously receive para-aortic radiation. Considering RT vs RT + chemo vs chemo alone

1 Answer available

How would you approach treatment for centrally recurrent cervical SCC with positive margins after excision that was not exenteration?

Recurrence was 2cm and PET confirmed local. Excision with positive margins. Current plan for salvage whole pelvic RT and vaginal cuff brachytherapy +/...

3 Answers available

Do you add chemotherapy to salvage EBRT/brachytherapy for a pt with small vaginal cuff recurrence of cervical CA s/p hysterectomy?

2 Answers available

What chemotherapy regimen would you utilize for a metastatic, poorly differentiated carcinoma of the cervix with neuroendocrine features?

If confirmed neuroendocrine and PD-L1 pending, how would you treat?

3 Answers available

In cervical cancer, is the presence of parametrial LNs with ITCs considered parametrial disease requiring adjuvant chemo +/- RT?

In patient with PD SCCA 15mm transverse; 5/20mm invasion; LVSI focally present; margins negative; 0/15 Left pelvic and 0/14 right pe...

2 Answers available

How do you plan urgent radiation therapy for vaginal bleeding caused by locally advanced cervical cancer?

What dose and technique do you use and how do you integrate the subsequent definitive treatment plan?

2 Answers available

When would you consider sequential chemotherapy and radiation rather than concurrent for early stage cervical cancer with high risk pathologic features?

The recently released STARS phase 3 RCT found improved DFS, decreased distant recurrence, with reduced toxicities for chemotherapy (cisplatin + taxol)...

2 Answers available

Do you ever offer minimally invasive surgery for treatment of early stage cervical cancer?

Despite the LACC trial, this year's SGO had many posters and discussions around MIS for early cervical cancer. If you offer MIS, what are the key ele...

2 Answers available

For gyn cancers receiving chemoradiation, how high can you boost grossly positive nodes with SIB if not near bowel?

SIBs of 55-57.5 Gy in 25 fractions are frequently mentioned with bowel volume constraints at this dose, but assuming there is no bowel nearby (e.g., b...

3 Answers available

How would you treat/counsel a patient with Stage IB3 SCC of the cervix who is 18 weeks pregnant and desires to maintain pregnancy?

1 Answer available

Would you consider robotic lymph node dissection and parametrectomy for a patient with incidental stage 1A2 cervical cancer after simple hysterectomy?

Margins negative, no LVSI, PET/CT negative.

2 Answers available

How would you manage a cervical cancer patient who develops new oligomet to the spine during primary cis/RT?

How would you factor in a patient with profound thrombocytopenia?

3 Answers available

How would you approach radiation in a patient with IIIC2 SCC of the cervix with a history of ileoanal reanastomosis and j pouch?

Paraaortic nodes positive to left renal vein

1 Answer available

What is your preferred treatment regimen for locally advanced (IIB-IVA) high-grade neuroendocrine carcinoma of the cervix (small cell type)?

Would PET-positive pelvic or paraaortic lymph nodes change this recommendation?

1 Answer available

How would you approach nodal assessment in a pregnant patient with new diagnosis of at least stage IB1 cervical SCC?

Currently 7 weeks pregnant, diagnosis based on CKC

1 Answer available

Would you offer definitive RT to a patient with metastatic cervical adenocarcinoma s/p carbo/taxol/avastin with a partial response in the metastatic sites?

ex. in a patient with pulmonary micronodules, inguinal, pelvic, PA nodes

3 Answers available

How would you approach a diagnostic excisional procedure for a pregnant patient with exam concerning for carcinoma and cervical biopsies (x 2) suspicious for foci of invasive disease?

Patient is currently 7 weeks GA with 1.5cm visible lesion. MFM recommends 13wk CKC vs LEEP with cerclage at that time.

1 Answer available

When can brachytherapy be used alone in the definitive treatment of FIGO IA1/IA2 medically inoperable cervical cancer?

1 Answer available

When do you include the mesorectum for definitive cervical cancer patients getting concurrent chemoradiation followed by brachy?

Particularly with IMRT when delineating volumes.

3 Answers available

Under what circumstances (if any) would you offer hysterectomy after completion of primary chemoradiation for locally advanced cervical cancer?

2 Answers available

Would you consider fertility-sparing management of stage IB1 cervical cancer using NACT followed by conization?

Lesion measures 2cm and PET is otherwise negative.

1 Answer available

How would you approach palliation of a symptomatic cervical cancer involving the supraclavicular lymph nodes?

Patient with stage IIB cervical cancer treated 8 years ago, now with large (>10cm), isolated, symptomatic recurrence involving the left SCL and med...

1 Answer available

How would you approach unresectable pelvic side wall recurrence in cervical cancer with previous definitive chemoradiation?

Would you consider SBRT or brachytherapy?

1 Answer available

Do you sample radiologically negative paraaortic nodes in cervical cancer patients with clinically positive pelvic nodes prior to initiating primary chemoradiation?

1 Answer available

What clinical factors would lead to utilizing a tandem and cylinder rather than tandem and ovoid for cervical cancer brachytherapy?

3 Answers available

Do you offer ovarian transposition to premenopausal cervical cancer patients prior to chemoradiation therapy?

What factors affect this decision?

2 Answers available

In patients with metastatic/persistant/recurrent cervical cancer who have completed platinum-based chemotherapy with bevacizumab, do you offer maintenance bevacizumab?

1 Answer available

How do you manage bladder fullness during cervical T&O brachytherapy to minimize OAR dose?

Small bowel is usually the dose limiting OAR while planning cervical HDR brachytherapy. Having the bladder empty during treatment planning and deliver...

2 Answers available

Would you give additional radiation for a positive margin after salvage hysterectomy for a patient with cervical cancer who had initial definitive chemoradiation with EBRT+T&R?

Would you consider additional EBRT or vaginal cuff HDR in a patient with previous tx with EBRT (45Gy) + HDR (30Gy) for a R1 resection with a radial ma...

2 Answers available

When, if ever, would you recommend hysterectomy after chemoradiation for patients with locally advanced cervical cancer?

This has been a common practice in the community. Is there a benefit for certain patients?

2 Answers available

Would you consider modifying T&O fractionation during the COVID-19 pandemic?

What dose/fractionation would you recommend?

2 Answers available

What are your next steps in management for a patient with endocervical adenocarcinoma s/p radical trachelectomy with a positive pelvic lymph node noted on final pathology?

Margins are negative.

1 Answer available

In what situations would you perform a sentinel lymph node biopsy for cervical cancer?

1 Answer available

Do you routinely discuss HRT with patients that have undergone surgical menopause due to treatment of cervical cancer?

1 Answer available

For an non-operative patient with IB1 cervical cancer, would you recommend RT alone or concurrent chemoRT for definitive therapy?

2 Answers available

How would you manage a small posterior vaginal defect noted at the time of cervical brachytherapy?

Patient being treated for cervical cancer noted to have a < 1 cm posterior vaginal fornix defect with a small focus epiploclia herniating into the ...

2 Answers available

Would you recommend adjuvant radiation for well-differentiated gastric-type adenocarcinoma of the cervix, stage 1b without LVI?

The limited data on MDA (minimum deviation adenocarcinoma) suggests it has a worse prognosis, but it is hard to disentangle this from stage, as it is ...

1 Answer available

Would you consider a single insertion HDR scheme for T&O brachytherapy (BID fractionation over 3 days)?

Would there be a substanital increase in the risk of toxicity using such a scheme? We frequently have patients who have to travel long distance...

1 Answer available

How do you choose 1st line therapy for recurrent cervical cancer?

Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...

1 Answer available

How do you determine which systemic therapy to recommend in the 2nd line setting for metastatic, PD-L1 NEGATIVE cervical cancer?

1 Answer available

What dose and OAR constraints you use for boost with IMRT or SBRT when a patient with cancer of the cervix is not candidate for brachytherapy?

Could you discuss how you decide between IMRT or SBRT boost for a patient who is not able to receive intracavitary or interstitial HDR or LDR brachyth...

1 Answer available

How would you approach treatment for a primary carcinosarcoma of the cervix with pelvic and para-aortic nodal involvement?

What chemotherapy and sequencing with radiation therapy would you recommend? IS surgery a component of the treatment?

1 Answer available

Is pembrolizumab considered standard of care in the 2nd line treatment of recurrent cervical cancer?

Does the phase II KN-158 provide sufficient evidence to change management?

1 Answer available

Would you recommend 1st line pembrolizumab for PD-L1 positive recurrent/metastatic cervical cancer patient who is not a candidate for or refuses chemotherapy?

1 Answer available

When do you recommend PD-L1 testing for patients with recurrent cervical cancer?

Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?

1 Answer available

In a pre-menopausal female with cervical cancer, would you boost a hypermetabolic ovary on PET?

Do you have an SUV cutoff for physiologic activity of the ovary?

1 Answer available

For stage IB1 cervical cancer s/p surgery with only 1 Sedlis criteria, should adjuvant pelvic EBRT or vaginal cuff brachytherapy be recommended in the presence of other adverse pathologic features, such as high tumor grade or very close but negative margins?

1 Answer available

Would you use different EBRT field edge for an HIV positive patient with FIGO IIIC1 (2018) cervical cancer with positive bilateral external iliac nodes?

Do you cover common iliac nodes (L3/L4) or keep field edge at L4/L5 to reduce bone marrow toxicity?

1 Answer available

Are you using the new FIGO 2018 staging or waiting until it is incorporated into the next AJCC edition?

4 Answers available

In light of the ongoing GOG 263 trial, do you consider adding concurrent chemo with RT for early stage cervical cancer as adjuvant after Rad Hyst off trial?

If so, what indications would you use other than Peters criteria?

1 Answer available

How do you define and IR-CTV for cervical brachytherapy?

Do you use a trimmed 10 mm expansion on HR-CTV? Do you also include the entire initial extent of disease? How much does your IR-CTV coverage affect yo...

1 Answer available

What volumes would you use for salvage radiation in a patient with a pelvic lymph node recurrence of cervical cancer initially treated with surgery alone?

What dose would you use?

1 Answer available

How do you match a para-aortic field to a previously irradiated whole pelvis field in a woman with PA nodal failure after definitive chemoRT for cervical cancer?

1 Answer available

How do you counsel a cervical cancer patient s/p definitive chemoRT who is not sexually active and refuses to use vaginal dilators to improve compliance?

2 Answers available

How would you treat an isolated port recurrence of an early stage cervical patient s/p WLE?

A literature search indicates that most port site recurrences are managed fairly aggressively with chemoRT or RT doses 45-66 Gy. This is understandabl...

1 Answer available

How do you sequence vaginal cuff brachytherapy with EBRT for post-op endometrial or cervical cases that require both modalities?

Sequentially or do you integrate the cuff brachy with the EBRT and if so what schedule, BIW, weekly, etc?

3 Answers available

How do you best manage bulky, clinical stage IIA squamous cell cancer of the cervical stump in a patient with a previous partial supra-cervical hysterectomy?

2 Answers available

Would you consider BID treatment for a patient with a pelvic SCC (e.g. cervix or anal) if a significant amount of treatment days have been missed?

For example, a patient with cervical or anal SCC who has missed many treatments due to side effects, low blood counts, hospitalizations, or non-compli...

1 Answer available

Do you take patients off anticoagulation for tandem and ovoid or tandem and ring procedures?

1 Answer available

What is your approach to a cervical SCC patient in which you're unable to properly place a T&O, due to obliterated cervical os, after completion of EBRT?

Do you add an IMRT boost with possibly vaginal brachytherapy?

2 Answers available

What is your protocol for conscious sedation during T&O insertion?

What are your specific protocols for monitoring and for dosing narcotics and sedatives?

2 Answers available

Are there instances where you prefer a SBRT boost rather than a brachytherapy boost when treating definitive locally advanced cervical cancer?

If so, what dose/ volume is prescribed? How do you account for motion?

1 Answer available

How would you approach the management of a patient with locally advanced cervical cancer as well as synchronous endometrial adenocarcinoma?

1 Answer available

What strategies have you found to be most helpful in improving patient compliance with vaginal dilator use after pelvic radiotherapy?

1 Answer available

When do you use a brachytherapy vaginal cuff boost in postoperative cervical cancer treatment?

Close but negative radial margins? LVSI? What fractionation/dose do you use for your vaginal cuff boost if used?

2 Answers available

What pelvic fields do you treat for patients with FIGO IA2-IB cervical cancer patients who inadvertently get a simple hysterectomy but with lymph node sampling (for presumed endometrial carcinoma)?

In the setting of a negative lymph node sampling, would you treat a full pelvis or mini-pelvis to compensate for lack of the appropriate surgery? Is a...

1 Answer available

Do you recommend adjuvant pelvic RT for Stage 1 cervical adenocarcinoma?

In patients who don't meet traditional criteria for adjuvant chemoradiation from Peters (GOG 109) and < 2 high risk factors from Rotman (GOG 92) fo...

1 Answer available

What is your technique to calculate the vaginal surface dose in gyn intracavitary brachytherapy?

What exactly do you contour and what is your dose constraint to that volume?

4 Answers available

What is the role of parametrial and pelvic side wall boosts in the setting of volumetric brachytherapy for locally advanced cervical cancer treated with either 3DCRT or IMRT?

Does using something like a vienna applicator allow you to avoid dose escalation with more external beam? How do you recommend doing a classic pa...

2 Answers available

What are you posterior field borders for endometrial and cervical cancer 3DCRT plans?

Some classic references recommend the coverage of the entirety of the sacrum but the volume delineation guidelines for both seem to only cover the mos...

1 Answer available

What is your strategy to deliver EBRT, brachytherapy, and a parametria/lymph node boost in less than 7-8 weeks for cervical cancer?

1 Answer available

What small bowel dose constraints do you use in gyn brachytherapy?

The most recent ABS guidelines don't discuss a dose constraint for the small bowel.

3 Answers available

If a patient with locally advanced cervical cancer cannot receive brachytherapy following 45Gy to the whole pelvis, how do you optimally deliver your boost?

Does your strategy change if bladder invasion is present?

1 Answer available

What indications do you use to prophylactically treat para-aortic lymph nodes in cervical cancer?

Do you treat PAs if pelvic nodes are positive? If common iliacs are involved? Only if there are positive PA nodes?

2 Answers available

What is the biggest mistake people make when using IMRT to treat cervical cancer?

1 Answer available

Papers discussed in this category

International journal of radiation oncology, biology, physics, 2011-02-01

Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer.

Int J Radiat Oncol Biol Phys, 2013 Jul 9

Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States.

JAMA Netw Open, 2021 Apr 01

Red Blood Cell Transfusion Practices for Patients With Cervical Cancer Undergoing Radiotherapy.

Int. J. Radiat. Oncol. Biol. Phys., 2014-05-01

Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMBRACE study.

Cancer Nurs, 2017-04-21

Dilator Use After Vaginal Brachytherapy for Endometrial Cancer: A Randomized Feasibility and Adherence Study.

Cochrane Database Syst Rev, 2010 Sep 08

Vaginal dilator therapy for women receiving pelvic radiotherapy.

International journal of radiation oncology, biology, physics, 2019-05-01

Single-Institution Experience in 3D MRI-Based Brachytherapy for Cervical Cancer for 239 Women: Can Dose Overcome Poor Response?

Cochrane Database Syst Rev, 2012 May 16

Radiotherapy and chemoradiation after surgery for early cervical cancer.

Int. J. Gynecol. Cancer,

Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients with intermediate-risk or high-risk factors: a 13-year experience.

Seminars in radiation oncology, 2019-04

Management of Nodal Disease in Advanced Cervical Cancer.

International journal of radiation oncology, biology, physics, 2006-08-01

Influence of margin status and radiation on recurrence after radical hysterectomy in Stage IB cervical cancer.

Gynecologic oncology, 2005-11

Cervical sarcomas: an analysis of incidence and outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2015-12-15

Prospective Validation of Pooled Prognostic Factors in Women with Advanced Cervical Cancer Treated with Chemotherapy with/without Bevacizumab: NRG Oncology/GOG Study.

Gynecologic oncology, 1999-05

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000-04

Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix.

Lancet,

Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer.

Gynecol. Oncol., 2005 Nov 21

Ovarian metastasis in carcinoma of the uterine cervix.

J. Clin. Oncol., 2011 Mar 28

Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix.

BMC Cancer, 2017 Apr 28

Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk, early stage uterine cervical cancer patients after radical hysterectomy.

N. Engl. J. Med.,

Improved survival with bevacizumab in advanced cervical cancer.

American journal of obstetrics and gynecology, 2011-08

Fertility preserving options in patients with gynecologic malignancies.

Journal of the National Cancer Institute. Monographs, 2005

Fertility-sparing surgery for malignancies in women.

Pediatric blood & cancer, 2018-09

Impact of ovarian transposition before pelvic irradiation on ovarian function among long-term survivors of childhood Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study.

Obstet Gynecol,

ACOG Committee Opinion No. 747: Gynecologic Issues in Children and Adolescent Cancer Patients and Survivors.

Clin Transl Radiat Oncol, 2018 Jan 11

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies.

Gynecologic oncology, 2014-01

Management of low-risk early-stage cervical cancer: should conization, simple trachelectomy, or simple hysterectomy replace radical surgery as the new standard of care?

Cancer, 2000-04-15

Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients.

Lancet Oncol.,

Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2019-01

Incidence of mesorectal node metastasis in locally advanced cervical cancer: its therapeutic implications.

Gynecologic oncology, 2004-04

Detection of pelvic lymph node micrometastasis in stage IA2-IB2 cervical cancer by immunohistochemical analysis.

J Obstet Gynaecol Res, 2019 Sep 09

Long-term oncological outcomes of minimally invasive radical hysterectomy for early-stage cervical cancer: A retrospective, single-institutional study in the wake of the LACC trial.

The New England journal of medicine, 2018-11-15

Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer.

International journal of radiation oncology, biology, physics, 1991-07

Radiotherapy alone for medically inoperable carcinoma of the cervix: stage IA and carcinoma in situ.

Cancer,

Results of treatment of early stage I carcinoma of the uterine cervix with intracavitary radium alone.

The Lancet. Oncology, 2017-03

A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.

Gynecologic oncology, 2017-04

Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2019-01-23

Conservative management of cervical cancer in pregnancy.

Ann Oncol,

Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting.

Gynecol Oncol, 2018 May 24

Simple trachelectomy with pelvic lymphadenectomy as a viable treatment option in pregnant patients with stage IB1 (≥2 cm) cervical cancer: Bridging the gap to fetal viability.

Int J Gynecol Cancer,

Laparoscopic pelvic lymphadenectomy in 32 pregnant patients with cervical cancer: rationale, description of the technique, and outcome.

Gynecologic oncology, 2011-07

Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document.

BMC Cancer, 2018 May 04

Neuroendocrine carcinoma of the cervix: a systematic review of the literature.

J Gynecol Oncol,

Advances in diagnosis and treatment of metastatic cervical cancer.

International journal of radiation oncology, biology, physics, 2008-11-15

Prospective clinical trial of positron emission tomography/computed tomography image-guided intensity-modulated radiation therapy for cervical carcinoma with positive para-aortic lymph nodes.

Int. J. Radiat. Oncol. Biol. Phys., 2012 Aug 14

Curative chemoradiotherapy in patients with stage IVB cervical cancer presenting with paraortic and left supraclavicular lymph node metastases.

Practical radiation oncology, 2017

Impact of treatment year on survival and adverse effects in patients with cervical cancer and paraortic lymph node metastases treated with definitive extended-field radiation therapy.

Practical radiation oncology, 2018

Definitive local therapy is associated with improved overall survival in metastatic cervical cancer.

The New England journal of medicine, 1999-04-15

Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.

Ann Oncol, 2012 Feb 21

A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study.

JAMA Oncol,

Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.

Lancet (London, England), 2017-10-07

Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-10

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study.

J Clin Oncol, 2019 Nov 04

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.

Lancet Oncol, 2021 Apr 09

Efficacy and safety of tisotumab vedotin in previously treated recurrent or metastatic cervical cancer (innovaTV 204/GOG-3023/ENGOT-cx6): a multicentre, open-label, single-arm, phase 2 study.

Int J Gynecol Cancer, 2019 Jan 04

Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL Trial.

Gynecologic oncology, 1998-08

Radiation therapy of pelvic recurrence after radical hysterectomy for cervical carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-08-01

Phase III study of cisplatin with or without paclitaxel in stage IVB, recurrent, or persistent squamous cell carcinoma of the cervix: a gynecologic oncology group study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-10-01

Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985-08

Randomized trial of three cisplatin dose schedules in squamous-cell carcinoma of the cervix: a Gynecologic Oncology Group study.

Cancer, 1981-08-15

Cis-platinum in treatment of advanced or recurrent squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.

Clin Transl Radiat Oncol, 2020 Apr 16

Long-term patient-reported distress in locally advanced cervical cancer patients treated with definitive chemoradiation.

Pract Radiat Oncol, 2019 Nov

Salvage Curative-Intent Reirradiation Stereotactic Body Radiation Therapy for Isolated Pelvic and/or Paraortic Recurrences of Gynecologic Malignancies.

Cancers (Basel), 2021 Mar 11

Image-Guided Brachytherapy for Salvage Reirradiation: A Systematic Review.

International journal of radiation oncology, biology, physics, 2017-12-01

Reirradiation Using Permanent Interstitial Brachytherapy: A Potentially Durable Technique for Salvaging Recurrent Pelvic Malignancies.

Journal of the National Comprehensive Cancer Network : JNCCN, 2006-05

Expanding role of positron emission tomography in cancer of the uterine cervix.

Radiology, 2018-04

Identification of Distant Metastatic Disease in Uterine Cervical and Endometrial Cancers with FDG PET/CT: Analysis from the ACRIN 6671/GOG 0233 Multicenter Trial.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019-04

Revised FIGO staging for carcinoma of the cervix uteri.

Gynecol Oncol, 2021 Jul 03

Sentinel lymph node mapping in early-stage cervical cancer - A national prospective multicenter study (SENTIREC trial).

Gynecol Oncol, 2017 Sep 24

Cycles of cisplatin and etoposide affect treatment outcomes in patients with FIGO stage I-II small cell neuroendocrine carcinoma of the cervix.

Surgical neurology international, 2017

Cervical cancer metastasis to the brain: A case report and review of literature.

Eur J Gynaecol Oncol,

Brain metastases from cervical carcinoma: overview of pertinent literature.

Obstet Gynecol,

Adjuvant Human Papillomavirus Vaccine to Reduce Recurrent Cervical Dysplasia in Unvaccinated Women: A Systematic Review and Meta-analysis.

Vaccines (Basel), 2021 Apr 21

Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis.

Vaccine, 2020 Aug 04

Prophylactic HPV vaccination after conization: A systematic review and meta-analysis.

N Engl J Med, 2021 Sep 18

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2017-03

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