Would you recommend consolidative RT for an HIV-positive patient with Stage I bulky DLBCL of the mediastinum s/p R-EPOCH?

The simple answer is that for most bulky limited-stage DLBCLs, I would favor consolidation ISRT (Preferred per UpToDate and +/- per NCCN). Some support for consolidation RT for bulky DLBCL after modern regimens incorporating rituximab comes from the following:

• A comparison of patients not receiving ...