Would you recommend prophylactic mastectomy if a patient's estimated lifetime risk of breast cancer using the Gail or Clause models approaches that of a person with a germline BRCA1 mutation (eg >65-85%), in the absence of high risk mutations?
Example patient: 50 year old pre-menopausal woman with a familiy history of pre-menopausal BRCA1 and BRCA2 wild-type breast cancers in sister and mother and a personal history of breast biopsies with an estimated lifetime risk for breast cancer is >50%.
1 Answer
Mednet Member
Medical Oncology · University of Michigan Medical School
Answered on
It is premature to recommend prophylactic mastectomies to this patient. The recommendation would be for recommendation of expanding genetic testing in the affected mother or sister utlizing a larger panel of breast cancer susceptibility genes, if they are available for testing and amenable to do so....
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