Would you still offer adjuvant chemoradiation therapy to a patient with pT3 pN1a rectal cancer who did not receive any neoadjuvant treatment, and whose adjuvant treatment is delayed by 4 months due to post-operative complications?

I don't think that this question can be answered fully as it is posed. As we have obtained more information on rectal cancer recurrence and the relative roles of adjuvant (or neoadjuvant) radiation therapy and chemotherapy, we need to be more selective as to who we treat if we are treating postoperatively. For example, we know that the risk of local recurrence is increased when the tumors are very low in the rectum, when the distance to the mesorectal fascia is small (<1-3 mm), and whether an experienced surgeon did a good TME. In addition, one would want to consider the overall physiological state of the patient at this point in time. In the present era, preoperative therapy, rather than postoperative, dominates the management, so there is...