Would you treat a localized radiographic prostate failure after EBRT with HDR brachytherapy?

I agree that a biopsy is needed and that you can't just rely on suspicious imaging findings. mp-MRI can underestimate the true extent of disease and is not 100% specific. Also if one is considering focal salvage, tt is critical to understand the full extent of recurrent disease. There are multiple s...

No, I would only treat after I have pathological confirmation.

This is a controversial issue. There are patient and tumour factors to consider before embarking on any salvage therapy. You need to consider whether the patient is an appropriate candidate (age, comorbidities, suitability for GA, side effects acute/chronic from initial treatment, urinary function a...