Would you treat an ER/PR+ inflammatory breast cancer that is HER2 2+ by IHC but 5% positive by FISH as HER2 positive?

Yes, because it is inflammatory breast cancer and the standard of care is to include neoadjuvant chemotherapy anyway. In this case, I'd use neoadjuvant TCHP and then retest breast biomarkers at surgery (MRM, with ALND, is standard surgery for inflammatory breast cancer at this time) to see if there ...