Would you treat endometrioid adenocarcinoma arising from an endometriosis lesion in a patient with prior hyst/BSO like an ovarian or endometrial primary?

For a patient with prior hyst/BSO and now an endometriosis-associated endometrioid adenocarcinoma, I would start by getting next-generation sequencing and MSI/MMR testing of the tissue specimen that was used to make the diagnosis. This would allow for additional information and the potential use of ...

In general, endometrioid adenocarcinomas arising in endometriosis after hysterectomy/BSO are classified as peritoneal carcinomas and are treated like ovarian cancer. Tumor molecular studies may add critical information in directing primary therapy.

Background:

Numerous epidemiologic studies have demon...

I've seen a few cases where patients with a history of prior TAH for non-oncologic reasons 2+ years earlier developed endometrioid adenocarcinoma of the vaginal cuff, +/- nodal regional disease.

We treat definitively similar to how we would approach vaginal recurrence of endometrial cancer assuming...