Would you use aspirin 81 mg for VTE prophylaxis in patients on adjuvant tamoxifen/SERMs?

In a meta-analysis of over 30,000 patients, VTE was found in 2.8% of patients on tamoxifen and 1.6% of patients on AI. So, yes there is a higher risk of VTE on tamoxifen but the percentage is still very low. I would not use 81 mg aspirin as VTE prophylaxis in all patients on tamoxifen to rescue or prevent a 2.8% increased risk with tamoxifen. We know that low-dose aspirin does carry a significant risk of bleeding.

In an article published in the British Journal of Clinical Pharmacology, the use of...